| 九种治疗糖尿病中成药中七种有害元素含量测定 |
| 投稿时间：2010-03-19 修订日期：2010-05-09 点此下载全文 |
| 引用本文：包丽丽,于昆,薛大方,李红,滕文锋.九种治疗糖尿病中成药中七种有害元素含量测定[J].药学实践杂志,2010,28(5):342~344 |
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| 中文摘要:目的:分析9种临床常用治疗糖尿病中成药中铅、镉、汞、砷、铀、钍、铊7种有害元素的含量,为现代用药提供参考数据。方法:采用微波消解处理中成药样品,电感耦合等离子体-质谱(ICP-MS)法对样品进行测定分析。结果:检测结果显示铅、镉、汞、砷铀、钍、铊7种有害元素在中成药样本中均有检出,其中铅、镉、汞、砷的含量符合绿色药用植物进口标准草案和东南亚进口中成药标准,但与我国九五攻关"中药材质量标准规范化"推荐标准草案和法国进口中药饮片标准相比还存在一定的差距。铀、钍、铊3种放射性元素比较结果显示,钍元素含量变化范围最大,元素含量均数比较结果Th>U>Tl。结论:将有害元素含量检测结果与国内外食品及药品相关标准进行对比发现其中存在一定的超标问题,铀等3种放射性元素含量很低,不会对人体造成危害。中成药加工生产过程中有害元素含量的质量控制应得到更多的重视。 |
| 中文关键词:ICP-MS 有害元素 糖尿病 中成药 |
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| Determination of seven baleful trace elements in nine Chinese patent medicine treating diabetes mellitus |
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| Abstract:Objective To determine Pb,Cd,Hg,As,U,Th,Tl in nine clinical commonly used Chinese traditional medicine treating diabetes mellitus,which provide reference data for modern medication.Methonds The samples were treated by microwave digestion,and determined by ICP-MS.Results The Results showed that the contents of seven elements Pb,Cd,Hg,As,U,Th,Tl in these samples were detected,in which Pb,Cd,Hg,As were all accord with the Import Standards Draft of Green Plants for medical use and Southeast Asia Import Standards for Chinese Patent Medicine,but still had gap with Recommending Standard Graft of Traditional Medicine Quality Standards and Import Chinese Traditional Medicine Standards of France.Compared three radioactive elements such as U,Th,Tl,which showed that Th had the largest scope of content,and mean comparative Results is Th>U>Tl.Conclusion Some problems still exist when making contrast between content of harmful elements with that in food and medical standards.The contents of U,Th,Tl in samples were low,and hadn't poison effect on human.Much importance should be attached on the quality control of baleful trace elements in the production of Chinese Patent Medicines. |
| keywords:ICP-MS baleful trace elements diabetes mellitus Chinese Patent Medicine |
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