| 新型基质复方丹参滴丸的药物动力学研究 |
| 投稿时间：2010-02-01 修订日期：2010-06-24 点此下载全文 |
| 引用本文：王巍,王晓华,张晓洁,陈建明.新型基质复方丹参滴丸的药物动力学研究[J].药学实践杂志,2010,28(5):331~333 |
| 摘要点击次数: 1461 |
| 全文下载次数: 613 |
|
|
| 中文摘要:目的:研究新型基质复方丹参滴丸的药物动力学。方法:以新西兰兔为实验动物,以市售复方丹参滴丸作为对照,采用高效液相色谱法进行分析。结果:两种基质滴丸的Cmax及Ka存在显著性差异(P<0.05),tpeak、AUC、t1/2β、MRT和VRT无显著性差异,新型基质滴丸剂的相对生物利用度为114.5%。结论:新基质滴丸的吸收速率常数和达峰浓度明显高于原滴丸,说明新型基质滴丸不仅保持并提高了原滴丸速效、高效的性能,且在达峰时间、在体内维持治疗浓度的时间及药物的消除情况与原滴丸基本相同。 |
| 中文关键词:新型基质 复方丹参滴丸 药物动力学 |
| |
| Study on pharmacokinetics of compound Danshen dropping pills of new matrix |
|
|
| Abstract:Objective To study the pharmacokinetics of compound Danshen dropping pills of new matrix.Methods HPLC was used as a detection method.New Zealand rabbits were taken as experimental animals.The compound Danshen dropping pills sold in market were taken as comparison products.Results There was a significant difference of Cmax and Ka between two kinds of pills(P<0.05).There was no significant different of tpeak、AUC、t1/2β,MRT and VRT.The relative bioavailability of compound Danshen dropping pills of new matrix was 114.5%.Conclusion The absorption rate constant and Cpeak of compound Danshen dropping pills of new matrix were much higher than the pills sold on the market.New matrix could improve the performance of quick Results and high efficiency of the dropping pills.The peak-time,the time of maintaining effective concentration and the elimination of drugs were same as old ones on the whole. |
| keywords:new matrix compound Danshen dropping pill pharmacokinetics |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
