| 他克莫司软膏治疗慢性手部湿疹的临床研究 |
| 投稿时间：2010-06-10 修订日期：2010-07-19 点此下载全文 |
| 引用本文：王秋枫,李丽,夏汝山,江彬彬,杨维玲.他克莫司软膏治疗慢性手部湿疹的临床研究[J].药学实践杂志,2010,28(4):288~290 |
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| 中文摘要:目的:评价0.1%他克莫司软膏治疗成人慢性手部湿疹的疗效和安全性。方法:86例慢性手部湿疹患者按就诊顺序进入试验组和对照组,分别接受0.1%他克莫司软膏(试验组)或丁酸氢化可的松乳膏(对照组)治疗;每日2次,疗程为4周;于治疗前及治疗后每周随访1次,疗效评估使用标准的手部湿疹评分系统(JHS),患者作视觉尺度VAS瘙痒症状测试及皮炎改善程度的自我评估,并记录不良反应。结果:经过4周的治疗后,试验组和对照组的有效率分别为83.7%和46.5%,试验组的有效率高于对照组(P<0.05)。治疗后,试验组的JHS明显下降,与患者自我评价符合,同对照组JHS相比,差异有统计学意义。试验组9例局部出现不同程度灼热、瘙痒等不适感,均于2~3d后消失;对照组3例出现一过性皮肤发红、刺痛,停药后消失。结论:0.1%他克莫司软膏治疗慢性手部湿疹安全且效果良好。 |
| 中文关键词:手部湿疹 他克莫司软膏 丁酸氢化可的松乳膏 |
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| Clinical study of tacrolimus ointment in the treatment of chronic hand eczema |
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| Abstract:ObjectiveTo evaluate the efficacy and safety of 0.1% tacrolimus ointment in the treatment of chronic hand eczema in patients.Methods A total of 86 patients with chronic hand eczema applied 0.1%tacrolimus ointment or hydrocortisone butyrate cream twice daily for 4 weeks.Eficacy was evaluated by the use of a standardized hand score(JHS).Results The clinical efficacy rates of 0.1% tacrolimus and hydrocortisone butyrate group in patients were 83.7% and 46.5%,0.1% tacrolimus was significantly more effective than control group in patients with chronic hand eczema(P<0.05).The hand eczema score in 0.1% tarcrolimus ointment group declined significantly compared with control group.The common but temporary side effects in tarcrolimus ointment group included skin itching and burning on the application site.Conclusions The Results show that 0.1% tacrolimus ointment in the treatment of chronic hand eczema in patients is effective and safe. |
| keywords:hand eczema tacrolimus ointment hydrocortisone butyrate cream |
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