| 他克莫司温度敏感眼用凝胶的体外释放研究 |
| 投稿时间：2009-12-27 修订日期：2010-04-15 点此下载全文 |
| 引用本文：张晶,宋洪涛,杨丽霞,周欣.他克莫司温度敏感眼用凝胶的体外释放研究[J].药学实践杂志,2010,28(4):267~270 |
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| 基金项目:福建省科技计划项目(2008Y0058) |
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| 中文摘要:目的:探讨各因素对他克莫司温度敏感眼用凝胶体外释放的影响。方法:采用无膜溶出模型,考察释放面积、振荡频率对眼用凝胶溶蚀及药物释放的影响。结果:随着释放面积和振荡频率的增加,凝胶溶蚀和药物释放增加。结论:药物释放主要取决于凝胶溶蚀。 |
| 中文关键词:他克莫司 温度敏感眼用凝胶 体外释放 凝胶溶蚀 HPLC |
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| Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel |
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| Abstract:ObjectiveTo study the factors that influence the release of tacrolimus from the thermosensitive ophthalmic gel.Methods The non-membrane model was introduced to observe the influence on the drug release and gel erosion for surface area and shaking frequency.Results The drug release and gel erosion were increased with the rise of surface area and shaking frequency.Conclusion The drug release mainly depends on the gel erosion. |
| keywords:tacrolimus(FK506) thermosensitive ophthalmic gel release in vitro gel erosion HPLC |
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