| 含β-丙氨酸的双链寡聚酰胺的合成 |
| 投稿时间：2009-11-04 修订日期：2010-01-22 点此下载全文 |
| 引用本文：李鹏,姜志辉,邱财荣,谢伟杰,祝绍隆,王亮,张大志.含β-丙氨酸的双链寡聚酰胺的合成[J].药学实践杂志,2010,28(3):217~219,231 |
| 摘要点击次数: 1254 |
| 全文下载次数: 384 |
|
| 基金项目:国家自然科学基金资助项目(NO.30672533);军队“十一五”课题06H013 |
|
| 中文摘要:目的:建立分子内含β-丙氨酸的双链寡聚酰胺的合成新方法和策略。方法:通过优化硝基氢化还原的方法,采用2+2片段偶合的策略,以1-羟基苯并三唑(HOBT)/N,N'-二环乙基碳酰亚胺(DCC)为缩合剂进行双链寡聚酰胺的合成。结果:高产率合成出了双链寡聚酰胺分子NO2ImPyβImPyγImPyβPyPyβCOOC2H5。结论:通过对反应温度、反应溶剂以及片段的选择优化,可以简便有效地合成分子内含有β-丙氨酸的双链寡聚酰胺。 |
| 中文关键词:β-丙氨酸 寡聚酰胺 N-甲基吡咯 N-甲基咪唑 合成 |
| |
| Synthesis of hairpin-polyamides containing β-alanine |
|
|
| Abstract:Objective To develop a new method and strategy for the synthesis of hairpin-polyamides containingβ-alanine.Methods The hairpin-polyamides were synthesized by the HOBT/DCC coupling reaction in good yields through the optimization of hydrogenation of nitro group and the 2+2 fragment coupling strategy.Results A hairpin-polyamide NO2ImPyβImPyγImPyβPyPyβCOOC2H2 was synthesized successfully with good yield.Conclusion The hairpin-polyamides containing β-alanine in the molecular can be easily and efficiently synthesized through the optimization of reaction temperature,solvent and fragment coupling strategy. |
| keywords:β-alanine polyamide N-methyl Pyrrole N-methyl imidazole,synthesis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
