| 中等取代度的羟丙基-β-环糊精对地塞米松的包埋特性研究 |
| 投稿时间：2009-11-18 修订日期：2010-01-23 点此下载全文 |
| 引用本文：张玥,韩静,张多婷,杨静,孙铭,项文娟.中等取代度的羟丙基-β-环糊精对地塞米松的包埋特性研究[J].药学实践杂志,2010,28(3):215~216,240 |
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| 中文摘要:目的:研究中等取代度的羟丙基-β-环糊精合成工艺及其对难溶性药物地塞米松的包埋性能。方法:合成了中等取代度的羟丙基-β-环糊精,并按照药典相关规定对产品质量进行了检测。用该产品包合难溶性药物地塞米松,并用相溶解度法对包合物进行了研究。结果:合成了取代度为7.875的羟丙基-β-环糊精,产品与地塞米松形成了1:1的包合物,提高地塞米松的溶解度约33倍。结论:合成的羟丙基-β-环糊精符合药典要求;通过羟丙基-β-环糊精的包合,提高了地塞米松的水溶性。 |
| 中文关键词:羟丙基-β-环糊精 取代度 包埋 地塞米松 |
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| The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone |
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| Abstract:Objective To investigate synthesis of medium substituted degree hydroxypropyl-β-cyclodextrins and the complex forming capability of dexamethasone.Methods Medium substituted degree hydroxypropyl-β-cyclodextrins were prepared and tested by pharmacopoeia.Dexamethasone were included with the product and performed by the phase-solubility diagram.Results The substituted degree of hydroxypropyl-β-cyclodextrins were 7.875.Dexamethasone was formed a 11 molar ratio inclusion complex with the product and improved solubility about 33 times.Conclusion The product accord with the request of pharmacopoeia.The dissolution capability of dexamethasone was increased by hydroxypropyl-β-cyclodextrins. |
| keywords:hydroxypropyl-β-cyclodextrins substituted degree complex forming dexamethasone |
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