| 葡萄糖氯化钠钾注射液与注射用盐酸头孢吡肟配伍的稳定性 |
| 投稿时间：2009-08-24 修订日期：2009-11-03 点此下载全文 |
| 引用本文：魏京海,毕开顺,马爱玲,陈晓辉.葡萄糖氯化钠钾注射液与注射用盐酸头孢吡肟配伍的稳定性[J].药学实践杂志,2010,28(3):213~214 |
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| 中文摘要:目的:研究在室温下葡萄糖氯化钠钾注射液(简称GNK)与注射用盐酸头孢吡肟配伍后的稳定性。方法:采用RP-HPLC法测定配伍后注射用盐酸头孢吡肟的含量变化,同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果:在室温下配伍溶液8 h内均无气体或沉淀产生,pH值、不溶性微粒和含量均无明显变化。结论: GNK与注射用盐酸头孢吡肟配伍后8 h稳定,在8 h内可安全应用于临床。 |
| 中文关键词:配伍稳定性 葡萄糖氯化钠钾注射液 盐酸头孢吡肟 |
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| Compatible stability of glucose and sodium potassium chloride injection mixing with cefepime Hydrochloride for injection |
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| Abstract:Objective To study the stability of glucose and sodium potassium chloride injection(GNK) mixing with cefepime hydrochloride in room temperature.Methods RP-HPLC was applied to determine the content change of cefepime hydrochloride in different time.The pH,quantity of non-soluble particulate and appearance of mixtures were also observed.Results In room temperature the mixtures produced neither gas nor sediment.The pH,quantity of non-soluble particulate and content did not change within 8 hours.Conclusion The mixtures of GNK mixing with cefepime hydrochloride are stable in 8 hours. |
| keywords:compatible stability GNK cefepime hydrochloride |
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