| 肾移植患者MDR1C3435T基因多态性对他克莫司血药浓度/剂量比及疗效的影响 |
| 投稿时间：2009-06-29 修订日期：2009-08-18 点此下载全文 |
| 引用本文：侯明明,宋洪涛,王庆华,杨顺良,谭建明.肾移植患者MDR1C3435T基因多态性对他克莫司血药浓度/剂量比及疗效的影响[J].药学实践杂志,2010,28(1):29~31 |
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| 中文摘要:目的研究肾移植术后患者MDR1C3435T基因多态性对他克莫司(FK506)血药浓度/剂量比(C/D)及急性排斥反应和不良反应的影响。方法采用聚合酶链反应(PCR)和限制性内切片段长度多态性(RFLP)的方法检测肾移植患者MDR1C3435T基因型,比较不同基因型患者之间FK506的C/D值以及急性排斥反应、不良反应的差异。结果MDR1C3435T各基因型组间FK506的C/D值及急性排斥反应、不良反应均无显著性差异。结论MDR1C3435T基因多态性与肾移植患者FK506的C/D值及急性排斥反应、不良反应间无显著相关性。 |
| 中文关键词:肾移植 他克莫司 MDR1 基因多态性 血药浓度/剂量比 疗效 不良反应 |
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| Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation |
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| Abstract:Objective To investigate the impact of MDR1C3435T genetic polymorphism on the concentration/dose(C/D) ratio,acute rejection and adverse effect of tacrolimus(FK506)in the renal patients after transplantation.Methods The MDR1C3435T genotype was determined by PCR-RFLP method.The differences of C/D ratio,acute rejection and adverse reaction were compared among all of the genotype groups treated with FK506.Results There was no significant difference in the C/D ratio,rejection and adverse reaction of FK506 among MDR1C3435T genotype groups.Conclusion There was no significant relation between the C/D ratio,acute rejection and adverse reaction of FK506 and MDR1C3435T genetic polymorphism in the transplant patients. |
| keywords:renal transplantation,tacrolimus MDR1 genetic polymorphism concentration/dose efficacy adverse reaction |
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