| 盐酸西替利嗪凝胶剂的制备及体外透皮特性 |
| 投稿时间：2009-04-03 点此下载全文 |
| 引用本文：高翔,张晨曦,杨明,刘继勇.盐酸西替利嗪凝胶剂的制备及体外透皮特性[J].药学实践杂志,2009,27(5):367~369 |
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| 基金项目:国家自然科学基金(30801557) |
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| 中文摘要:目的:制备盐酸西替利嗪凝胶剂,研究其体外透皮特性。方法:以卡波姆940为辅料制备西替利嗪凝胶剂,采用改良Franz扩散池,以离体大鼠皮肤为透皮屏障,采用HPLC法测定西替利嗪的透皮行为。结果:西替利嗪凝胶体外透皮释药方程为Q=110.03t+17.17(r=0.99),透皮速率为110.03μg/(cm2.h)。结论:西替利嗪凝胶具有良好的透皮效果,其体外经皮渗透符合一级动力学过程。 |
| 中文关键词:盐酸西替利嗪 凝胶剂 体外透皮 |
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| Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel |
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| Abstract:Objective:To prepare cetirizine hydrochloride gel and study its skin penetration in vitro.Methods: Cetirizine gel was prepared with carbopol 940 as base material.Using Franz diffusion cell and excised rat skin in vitro as transdermal barrier.The cumulative permeation quantity of cetirizine was determined by HPLC.Results:The penetration equation of cetirizine gel was Q=110.03t+17.17(r=0.99).Conclusion:The penetration of cetirizine from the gel through the rat skin followed first-order kinetics. |
| keywords:cetirizine hydrochloride gels in vitro skin penetration |
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