| 传统中药川乌炮制前后的离子阱质谱研究 |
| 投稿时间：2009-07-07 点此下载全文 |
| 引用本文：董昕,刘敏,赵靖霞,张薇,娄子洋.传统中药川乌炮制前后的离子阱质谱研究[J].药学实践杂志,2009,27(5):349~352 |
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| 中文摘要:目的:通过应用电喷雾-离子阱质谱,研究了炮制前后的川乌药材成分,以揭示川乌炮制减毒的原理。方法:对3种乌头对照品进行了离子阱多级质谱分析,归纳其裂解规律。对炮制前后的川乌药材进行液-质联用分析,并对各色谱峰进行归属。结果:通过对比炮制前后的质谱总离子流图及紫外色谱图,提出了川乌炮制减毒的两方面原因。结论:同时指出了将液-质联用技术引入中药炮制品的质量控制是十分必要的。 |
| 中文关键词:川乌 离子阱质谱 炮制品 |
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| Research on constituents of Radix Aconiti and its processing by electrospray ionization trap mass spectrometry |
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| Abstract:Objective: To reveal the processing principleg of preparation of Radix Aconiti by electrospray ionization trap mass spectrometry.Methods: The three reference standars were made MSn analysis and elucidating the fragmentation pathways.The rapid analysis by HPLC-ESI-MS had been used for identification of contituents in Radix Aconiti.Results:The comparison of mass spectra and liquid chromatographic information revealed the differences of Radix Aconiti and its process product.Conclusion: It is necessary to make quality control of process product of traditional Chinese herbal medicines by HPLC-ESI-MS. |
| keywords:Radix Aconiti electrospray ionization trap mass spectrometry process product |
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