| 山萘酚-3-O-芸香糖苷磷脂复合物的制备与理化性质研究 |
| 投稿时间：2009-02-19 点此下载全文 |
| 引用本文：傅秋生,衣淑珍.山萘酚-3-O-芸香糖苷磷脂复合物的制备与理化性质研究[J].药学实践杂志,2009,27(3):186~188 |
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| 中文摘要:目的:山萘酚-3-O-芸香糖苷磷脂复合物的制备和理化性质考察。方法:制备山萘酚-3-O-芸香糖苷的磷脂复合物,测定其与山萘酚-3-O-芸香糖苷的溶解度,并对两者的水油分配系数进行分析。结果:与山萘酚-3-O-芸香糖苷相比,磷脂复合物不仅在正辛醇中溶解性有明显改善,在水中溶解度也有所升高;在不同pH的水-正辛醇系统中,复合物的表观油-水分配系数与山萘酚-3-O-芸香糖苷相比有一定的差异。结论:山萘酚-3-O-芸香糖苷磷脂复合物可明显改善山萘酚-3-O-芸香糖苷在水及正辛醇中的溶解性能。 |
| 中文关键词:山萘酚-3-O-芸香糖苷 磷脂复合物 理化性质 |
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| Preparation and physicochemical properties of kaempferol-3-O-rutinoside phospholipids complex |
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| Abstract:Objective:To prepare kaempferol-3-O-rutinoside phospholipid complex and study its physic chemical properties.Methods:Solubility and water oil distribution coefficient of the complex were studied,and compared with kaempferol-3-O-rutinoside.Results:There were a great improvements in the solubility of kaempferol-3-O-rutinoside phospholipid complex both in water and in n-octanol.Some differences of apparent oil/water distribution coefficients in the systems consisted of different pH water and n-octanol were found between the complex and kaempferol-3-O-rutinoside.Conclusion:The drug-phospholipid complexes may show some superior chemico-physical properties and enhance the absorption of the drugs. |
| keywords:kaempferol-3-O-rutinoside phospholipids complex physicochemical properties |
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