| 咖啡因口崩片的研究 |
| 投稿时间：2008-09-16 点此下载全文 |
| 引用本文：刘职瑞,叶显撑,王芳,张宁,樊旭嬿,鲁莹,钟延强,邹豪.咖啡因口崩片的研究[J].药学实践杂志,2009,27(3):179~182,217 |
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| 中文摘要:目的:本实验以咖啡因为模型药物,优化及研制咖啡因口腔崩解片。方法:采用低取代羟丙基纤维素、微晶纤维素(MCC)作为崩解剂,用干粉直接压片法制备咖啡因口腔崩解片。采用正交实验优化处方组成,以达到最短的崩解时间。通过质量研究,建立了初步的质量标准。结果:处方中主药咖啡因的含量固定为100 mg,MCC为40 mg,L-HPC为25 mg,甘露醇为105 mg,硬度固定在3 kg/cm2。按拟定的质量标准对咖啡因口崩片质量检查结果表明,咖啡因口崩片质量可控。结论:咖啡因口崩片的制剂简单、质量可控。 |
| 中文关键词:口腔崩解片 崩解剂 正交设计 质量标准 |
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| Studies on orally disintegrating tablet of caffeine |
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| Abstract:Objective:To optimize the formula of caffeine orally disintegrating tablet and to investigate the related indexes.Methods:Taking the contents of L-HPC,MCC(disintegrating agent)as disintegrants and the disintegrating time(td)as evaluation indexes to carry out the orthogonal experiment to optimize the formula.The dissolution curve of the optimized formula was drawn.Results:The optimized formula for caffeine orally disintegrating tablet was as follows:the contents of caffeine,MCC,L-HPC,and mannitol were 100,40,25,and 105 mg,respectively.The prepared orally disintegrating tablets disintegrated completely within 30 s and dissolved basically within 2 min.Conclusion:This preparation method of oralhy disintegranting tablet of caffeine is simple and available.Determination method has high accuracy and recovery.It is a suitable method for the preparation and content determination of caffeine orally disintegranting tablet. |
| keywords:orally disintegrating tablet caffeine |
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