| 复方茵虎汤对实验性肝损伤的保护作用 |
| 投稿时间：2008-09-25 点此下载全文 |
| 引用本文：公衍玲,王宏波.复方茵虎汤对实验性肝损伤的保护作用[J].药学实践杂志,2009,27(2):123~125 |
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| 中文摘要:目的:本实验研究复方茵虎汤(复方茵虎汤)对四氯化碳致小鼠肝损伤的保护作用。方法:以腹腔注射四氯化碳(CCl4)建立小鼠肝损伤模型,以复方茵虎汤作为受试药物,以联苯双酯作为阳性对照药物,以肝指数(LI)、血清中谷氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、肝组织匀浆中超氧化物歧化酶(SOD)和丙二醛(MDA)水平为检测指标,观察复方茵虎汤对肝损伤的保护作用。结果:复方茵虎汤能够明显降低CCl4致小鼠肝损伤血清中ALT和AST水平,升高肝组织中SOD水平,降低肝组织中MDA水平,减轻四氯化碳对肝脏细胞的病理损伤。结论:复方茵虎汤对CCl4致小鼠急性肝损伤有一定的保护作用。 |
| 中文关键词:复方茵虎汤 作用 茵陈 虎杖 四氯化碳 急性肝损伤 |
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| Protective effect of compound Yinhu decoction on experimental liver injury |
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| Abstract:Objective: To observe the protective effect of Compound Yinhu decoction on acute liver injury induced by carbon tetrachloride(CCl4) in mice.Methods: Acute liver injury was established by intraperitoneal injection of CCl4.Compound Yinhu decotion was tested as subjects drug and bifendate as a positive control drug.The liver index(LI),the levels of serum alanine amino-transferase(ALT) and aspartate amino-transferase(AST),the superoxide dismutase(SOD) and molondialdehyde(MDA) levels in the liver tissue were measured and the protective effect of Compound Yinhu decotion on liver injury was observed.Results:Compound Yinhu decotion could significantly reduce serum ALT and AST levels,increase liver SOD level and decrease liver MDA level.It could also reduce the liver cell morphological injury.Conclusions:Compound Yinhu decotion has some protective effect on acute liver injury induced by CCl4 in mice. |
| keywords:Compound Yinhu decotion effect Herba Artemisiae Scopariae Rhizoma Polygoni Cuspidati carbon tetrachloride acute liver injury |
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