| 阿德福韦酯自乳化制剂的研究 |
| 投稿时间：2008-09-22 点此下载全文 |
| 引用本文：王金锐,陈建明,张悦.阿德福韦酯自乳化制剂的研究[J].药学实践杂志,2009,27(2):118~121 |
| 摘要点击次数: 1576 |
| 全文下载次数: 652 |
|
|
| 中文摘要:目的:研究阿德福韦酯自乳化制剂,探求其最佳处方配比。方法:通过对油相、水、乳化剂的选择和配比优化,成功地将阿德福韦包埋在乳液中,由三元相图得到相应的自乳化区域,并结合自乳化速率、粒径测定、及溶解度试验的考察筛选处方,寻找出最佳的搭配和处方配比。结果:优选的阿德福韦酯自乳化制剂处方中油相为辛酸甘油三酯,表面活性剂为聚氧乙烯(35)蓖麻油。最终确立阿德福韦酯自乳化制剂的最优配方比为:辛酸甘油三酯:聚氧乙烯(35)蓖麻油(7:3)。结论:初步成功地制备了阿德福韦酯自乳化制剂。 |
| 中文关键词:阿德福韦酯 自乳化制剂 粒径测定 三元相图 |
| |
| Studies on the self-emulsifying drug delivery systems of adefovir dipivoxil |
|
|
| Abstract:Objective: To search for the optimum formula ratio for the self-emulsifying drug delivery systems of adefovir dipivoxil.Methods: The recipe of the self-emulsifying drug delivery systems of adefovir dipivoxil formation was optimized by studying the pseudo-ternary phase diagram,the self-emulsifying rate,particle size.Adefovir was successfully embedded in the SEDDS emulsion.Results:The optimized prescription was tricaprylin as oil,Cremophor EL35 as surfactant,with the oil and the surfactant ratio was 73.Conclusions:The preliminary adefovir dipivoxil Self-emulsifying prepartion has been prepared. |
| keywords:adefovir dipivoxil self-emulsifying drug delivery systems droplet size pseudo-ternary phase diagram |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
