海燕化学成分研究
投稿时间:2008-04-15    点此下载全文
引用本文:汤华,王旭东,陆祎,程萍,林厚文.海燕化学成分研究[J].药学实践杂志,2009,27(2):99~100,103
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作者单位E-mail
汤华 第二军医大学药学院海洋药物研究中心,上海200433 franklin67@126.com. 
王旭东 中国人民解放军第425医院药械科,海南三亚572008  
陆祎 第二军医大学长征医院药学部海洋药物实验室,上海200433  
程萍 第二军医大学长征医院药学部海洋药物实验室,上海200433  
林厚文 第二军医大学长征医院药学部海洋药物实验室,上海200433  
基金项目:国家高技术研究发展计划“863”资助课题(2006AA09Z423);长征医院“三重三优”学科人才建设计划资助课题
中文摘要:目的:研究海燕的化学成分。方法:采用多种层析方法分离海燕乙醇提取物,根据理化性质和光谱数据分析鉴定化合物的结构。结果:分离鉴定了7个化合物,分别为:3-十八烷氧基-1,2丙二醇(1),3β-羟基-胆甾-7烯(2),asterosaponinP1(3),5α-胆甾烷-3β,4β,6α,7α,8β,15β,16β,26-八醇(4),5α-胆甾烷-3β,6α,7α,8β,15α,16β,26-七醇(5),色氨酸(6),苯丙氨酸(7)。结论:化合物1、2为首次从海燕中分离得到,化合物4为首次从中国海域的海燕中分离得到。
中文关键词:海燕  海星  化学成分  结构鉴定
 
Study on the chemical constituents of marine starfish Asterina pectinifera
Abstract:Objective: To study the chemical constituents of marine starfish Asterina pectinifera.Methods: The constituents were separated and purified by column chromatography with silica gel and sephadex LH-20.Their structures were identified by spectrum and physical data.Results:Seven compounds were identified as : 3-(octadecyloxy)-1,2-Propanediol(1),5α-Cholest-7-en-3β-ol(2),asterosapoin P1(3),5α-cholestane-3β,6α,7α,8,15α,16β,26-heptol(4),5α-cholestane-3β,4β,6α,7α,8,15β,16β,26-octol(5),tryptophan(6),phenylalanine(7).Conclusions:Compounds 1 and 2 were isolated from Asterina pectinifera for the first time,while compound 4 was first obtained from Asterina pectinifera of China Sea.
keywords:Asterina pectinifera  starfish  chemical constituents  structure identification
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