| 取代咪唑酮合成工艺研究 |
| 投稿时间：2008-09-28 点此下载全文 |
| 引用本文：栗亚男,李耀武,郑灿辉,吕加国,唐辉,张珏,周有骏.取代咪唑酮合成工艺研究[J].药学实践杂志,2008,(6):447~449 |
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| 基金项目:上海市重点学科资助项目(B906). |
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| 中文摘要:目的:优化取代咪唑酮类化合物的合成工艺。方法:采用正交设计法,重点考察反应溶剂,投料比例及温度对收率的影响。结果:投料比例对收率的影响最为显著。结论:使收率由低于10%提高到42.5%,使得更加符合工业生产的要求。 |
| 中文关键词:取代咪唑酮 合成 正交分析 |
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| Study on the synthesis of replaced imidazole |
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| Abstract:Objective:To optimize the synthesis of replaced imidazole.Methods:Orthogonal experimental design was used and the influence of temperature,reactant ratio and solvent on the yield were investigated.Results:Reactant ratio was more important than the others.The yield was improved from less than 10%to 42.5%.Conclusion:The optimal preparation procedure is stable and available for industrial production. |
| keywords:replaced imidazole synthesis orthogonal experimental design |
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