| pH对酒石酸溴莫尼定滴眼液稳定性的影响 |
| 投稿时间：2007-12-17 点此下载全文 |
| 引用本文：税庆华,苏淮,李津,蓝伟伟,武利芬.pH对酒石酸溴莫尼定滴眼液稳定性的影响[J].药学实践杂志,2008,(5):364~366 |
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| 中文摘要:目的:考察pH对酒石酸溴莫尼定滴眼液稳定性的影响,确定本品最佳的pH范围及贮存条件。方法:采用HPLC法测定酒石酸溴莫尼定滴眼液的含量及有关物质,考察本品在强光、高温条件下的稳定性。结果:酒石酸溴莫尼定滴眼液对强光、高温较敏感,且随着pH值的升高,稳定性下降。结论:本品最适宜的pH范围为偏酸性,最适宜的贮存条件为低温、避光。 |
| 中文关键词:酒石酸溴莫尼定滴眼液 pH 稳定性 |
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| Effect of pH on the stability of brimonidine tartrate eye drops |
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| Abstract:Objective:To study the effect of pH on stability of brimonidine tartrate eye drops and to determine the optimal range of pH and storage conditions of it.Methods:HPLC methed was used for the determination of content and related substance of brimonidine tartrae eye drops.The stability of the preparation at high temperature and intense light illumination was studied.Results:Brimonidine tartrae eye drops was sensitive to high temperature and strong illumination.The stability of the preparation would get lower with the in- crease of pH.Conclusion:The optimum pH of the preparation was partial to acidity,and the optimum storage condition was low tem- perature and away from light. |
| keywords:brimonidine tartrate pH stability |
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