| 桂利嗪与尼莫地平对离体血管的舒张作用 |
| 投稿时间：2006-11-29 点此下载全文 |
| 引用本文：徐善超,高跃进,顾艳铃.桂利嗪与尼莫地平对离体血管的舒张作用[J].药学实践杂志,2008,(5):343~345,349 |
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| 中文摘要:目的:比较桂利嗪与尼莫地平对于离体血管的舒张作用。方法:分离SD大鼠胸主动脉,在内皮完整及去内皮的血管环上分别加入桂利嗪及尼莫地平,以累积剂量法给药至最大舒张剂量,观察药物对两种离体血管的舒张作用。结果:尼莫地平与桂利嗪均能剂量依赖性舒张内皮完整及去内皮血管。尼莫地平对内皮完整血管的舒张作用强于去内皮血管的舒张作用。桂利嗪对去内皮血管的舒张作用与内皮完整血管的作用相似。结论:尼莫地平的扩血管作用部分为内皮依赖性的,部分为对平滑肌的直接扩张作用;桂利嗪的扩血管作用主要是通过对平滑肌的直接扩张作用实现的。 |
| 中文关键词:尼莫地平 桂利嗪 血管内皮 舒张作用 |
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| Different relaxation effect of cinnarizine and nimodipine on isolated arteries |
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| Abstract:Objective:This study was designed to investigate the different relaxation effect of cinnarizine and nimodipine on isolated arteries.Methods:Arteries were isolated from sixteen male Sprague-Dawley rats weighing 220～250 g,carefully dissected from sur- rounding fat and connective tissues,and cut into 2～3 mm-long circular segments.These segments were initially contracted with pheny- lephrine(1μM).When the contraction reached a steady state,cumulative concentration-respense(CR)curves to cinnarizine or ni- modipine were obtained by adding increasing concentrations to the segments that functional endothelium was present or absent.Re- sults:Both cinnarizine and nimodipine produced concentration-dependent relaxation on the segments that functional endothelium was present or absent.Nimodipine produced stronger relaxation on endothelium complete segments than on the endothelium removal ones. Cinnarizine produced a same relaxation on endothelium-complete segments and endothelium-removed ones.Conclusion:Cinnarizine and nimodipine produced different relaxation effects on endothelium-complete segments and endothelium-removed ones.The differ- ence between cinnarizine and nimodipine was depended on the integrity of the vascular endothelium. |
| keywords:nimodipine cinnarizine vascular endothelium relaxation |
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