| 水飞蓟宾葡甲胺的制备与精制 |
| 投稿时间：2008-04-28 点此下载全文 |
| 引用本文：张晶,王巍,耿新辉.水飞蓟宾葡甲胺的制备与精制[J].药学实践杂志,2008,(4):274~277 |
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| 中文摘要:目的:研究水飞蓟宾葡甲胺的制备与精制。方法:先用无水乙醇溶解水飞蓟宾粗品进行重结晶精制,用精制的水飞蓟宾和葡甲胺结合成复盐。结果:实验中合成的产物经紫外分光度计检测水飞蓟宾葡甲胺含量高于96%,HPLC检测水飞蓟宾葡甲胺含量80%,总质量得率约为72.1%。结论:实验证明此水飞蓟宾葡甲胺的制备工艺稳定,各步工艺操作条件易控,产品质量可靠,适宜于工业化生产。 |
| 中文关键词:水飞蓟宾葡甲胺 制备 精制 |
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| The preparation and purification of silybin meglumine |
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| Abstract:Objective:To study the preparation and purification of silybin meglumine.Methods:IThe procedure of the preparation included two steps:first,the crude silybin was recrgstallized with absolute alcohol,and activated carbon which was used to adsorb im- purity simultaneously.Then,the purificatory product and meglumine were used to preparation silybin meglumine.Results:The content of silybin meglumine in preparation products was higher than 96% detected by ultraviolet spectrometer and 80% detected by high per- formance liquid chromatography (HPLC).The mass rate is approximately 72.1%.Conclusion::This experiment proved that the pro- duction process of silybin meglumine was stable,each step of operating conditions was easy to control.The product quality was reliable and suitable for industrial production. |
| keywords:silybin meglumine preparation,purification |
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