| 正交设计优化甲磺酸地拉韦啶分散片处方 |
| 投稿时间：2008-04-28 点此下载全文 |
| 引用本文：管清香,林天慕,王恩思.正交设计优化甲磺酸地拉韦啶分散片处方[J].药学实践杂志,2008,(4):261~263,277 |
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| 作者 | 单位 | E-mail | | 管清香 | 吉林大学药学院,吉林,长春130021
吉林大学生命科学学院,吉林,长春130013 | wangss@jlu.edu.cn | | 林天慕 | 吉林大学生命科学学院,吉林,长春130013 | | | 王恩思 | 吉林大学药学院,吉林,长春130021
吉林大学生命科学学院,吉林,长春130013 | |
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| 基金项目:吉林省卫生厅重点实验室项目(2005055) |
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| 中文摘要:目的:筛选甲磺酸地拉韦啶薄膜衣分散片的处方并进行制备。方法:以崩解时限为指标,采用正交设计实验,对分散片处方进行筛选,并进行体外溶出度考察。结果:按优选处方制备的3批分散片外观光洁,均在3 min内完全崩解并通过710μm筛。结论:研制的甲磺酸地拉韦啶分散片处方合理、工艺可行,符合分散片的质量要求。 |
| 中文关键词:甲磺酸地拉韦啶 分散片 体外溶出度 |
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| The formula optimization of delavirdine mesylate dispersible tablets by orthogonal design test |
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| Abstract:Objective:To optimize the formula and prepare delavirdine mesylate dispersible tablets.Methods:The formula of delavirdine mesylate dispersible tablet was optimized in term of disintegrating time by orthogonal design test.The dissolution rates of the principal agent in dispersible tablets were determined.Results:The optimized dispersible tablets had fine appearance and disintegrated in 3 min,and the suspension screened through the 710μm mesh.The dissolution rates of the dispersible tablets were similar in 3 bat- ches formulation.Conclusion::The prepared delavirdine mesylate dispersible tablet was reasonable in formula,feasible in technology and was accorded with the quality standards. |
| keywords:delavirdine mesylate dispersible tablet dissolution rate in vitro |
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