| 萘普生钠片溶出度测定及体内外相关性评价 |
| 投稿时间：2007-07-24 点此下载全文 |
| 引用本文：乐健,刘茜,石劲敏,陈桂良.萘普生钠片溶出度测定及体内外相关性评价[J].药学实践杂志,2008,(3):211~213 |
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| 中文摘要:目的:进行萘普生钠片体外溶出度的测定及体内外相关性评价。方法:按USP29版萘普生钠片溶出度测定法测定萘普生钠片体外溶出度,用HPLC法测定萘普生钠片在人体内的血药浓度,并用BAPP2.0程序进行拟合。结果:以体内吸收分数(F)对体外累积溶出率(X)进行线性回归,得方程F=0.330 3X+0.699 8(r=0.991 5),体内吸收分数与体外累积溶出率具有良好的相关性。结论:USP29版萘普生钠片的溶出度方法合理,可以较好反映体内吸收情况。 |
| 中文关键词:萘普生钠片 体外溶出度 体内外相关性 |
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| Dissolution of naproxen sodium tablets and evaluation of in vitro-in vivo correlation about this drug |
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| Abstract:Objective: To study the dissolution of naproxen sodium tablets and evaluate in vitro / in vivo correlation.Methods: Dissolution test method in naproxen sodium tablets adopted by USP was used for determination of dissolution in vitro.The concentrations of naproxen sodium tablets in human plasma were determined by HPLC.Results:The linear equation based on the dissolution rate(X) and absorption percentage(F) was F=0.330 3X+0.699 8 and the correlation coefficient was 0.991 5.Conclusion:To a certain extent,the in vitro dissolution test in USP could reflect the in vivo absorption. |
| keywords:naproxen sodium tablets dissolution in vitro and in vivo correlation |
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