| 葛根素微乳的制备 |
| 投稿时间：2008-03-24 点此下载全文 |
| 引用本文：陈菡,钟延强,鲁莹.葛根素微乳的制备[J].药学实践杂志,2008,(3):200~203 |
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| 中文摘要:目的:制备葛根素微乳口服给药系统(PUE-ME)。方法:通过溶解度实验、处方配伍实验和伪三元相图的绘制,以乳化时间、色泽为指标,筛选油相、表面活性剂、助表面活性剂的最佳搭配和处方配比。结果:葛根素在微乳中的溶解度最高可达77.11 mg/mL。结论:所制备的PUE-ME对葛根素增溶效果显著,将为PUE的口服制剂的进一步开发提供依据。 |
| 中文关键词:葛根素 微乳 增溶 |
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| Preparation of Puerarin by microemulsion drug delivery system |
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| Abstract:Objective: To develop a microemulsion drug delivery system of Puerarin(PUE-ME).Methods:Formulation of PUE-ME was screened by solubility experiments,compatibility tests and pseudo-ternary phase diagrams,with the consequence of visual examination as parameter.Results: The maximum drug corporation was 77.11 mg/mL.The formulation was composed of IPM(10%),brij-96V(37.5%),ethanol(37.5%),and water(25%).Conclusion:The formulation of PUE-ME preparation could meet the general requirements of the design. |
| keywords:puerarin microemulsion solubilization |
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