| 积雪草总三萜酸及其主要成分的抗抑郁活性研究 |
| 投稿时间：2007-07-24 点此下载全文 |
| 引用本文：曹尉尉,陆波.积雪草总三萜酸及其主要成分的抗抑郁活性研究[J].药学实践杂志,2008,(3):185~187 |
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| 基金项目:上海市自然科学基金(064119608) |
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| 中文摘要:目的:探讨积雪草总三萜酸和其主要成分积雪草酸、羟基积雪草酸的抗抑郁作用。方法:采用小鼠强迫游泳实验、小鼠悬尾实验、开野实验和拮抗利血平所致的小鼠眼睑下垂实验,分别以小鼠不动时间、自主活动数和拮抗率作为评价指标。结果:在强迫游泳实验中积雪草总三萜酸、积雪草酸、羟基积雪草酸60 mg/kg、120 mg/kg剂量均能显著缩短小鼠不动时间,在悬尾实验中30 mg/kg、60 mg/kg、120 mg/kg剂量均能显著缩短小鼠不动时间,开野实验结果表明给药后小鼠的自主活动无明显变化,在利血平拮抗实验中积雪草总三萜酸、积雪草酸、羟基积雪草酸均可减少小鼠眼睑下垂。结论:积雪草总三萜酸、积雪草酸、羟基积雪草酸有抗抑郁作用。 |
| 中文关键词:积雪草总三萜酸 积雪草酸 羟基积雪草酸 抗抑郁 |
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| Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents |
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| Abstract:Objective: To investigate the antidepressant activity of Centalla asiatic triterpenic acid(CATA),and its main comstituerts asiatic acid(AA) and madecassic acid(MA).Methods:The forced swimming test(FST),tail suspension test(TST),open field activity(OFA) test and reserpine-induced ptosis test were carried out to examine the antidepressant activity in mice.Mice immobility duration in FST and TST,spontaneous activity frequency in OFA,and ptosis in reserpine antagonistic test were observed.Results: CATA,AA and MA could significantly shorten mice immobility time in FST at the dosages of 60 and 120 mg/kg and could markedly shorten mice immobility time in TST at the dosages of 30,60 and 120 mg/kg.They could not reduce mice spontaneous activity in OFA.CATA,AA and MA could reduce ptosis mice in reserpine antagonistic test.Conclusion:CATA,AA and MA exert an antidepressant activity in animal models. |
| keywords:centalla asiatic triterpenic acid asiatic acid madecassic acid antidepressant effect |
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