| 甲硝唑羧甲基壳聚糖缓释微球的制备及体外释放 |
| 投稿时间：2008-08-28 点此下载全文 |
| 引用本文：康现武,王强,王毅,顾其胜,蒋丽霞.甲硝唑羧甲基壳聚糖缓释微球的制备及体外释放[J].药学实践杂志,2008,(3):182~184 |
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| 中文摘要:目的:探讨乳化交联法制备甲硝唑羧甲基壳聚糖微球的最佳工艺,并了解微球体外释药规律。方法:按正交设计,考察不同羧甲基壳聚糖浓度、投药比、交联度、乳化转速等条件对质量指标的影响,选出最佳方案,并进一步检测微球的体外释放特性。结果:各因素对所制微球综合评分指标的影响大小依次为:乳化转速>投药比>交联度>羧甲基壳聚糖浓度,用优化的工艺制得微球50-200μm粒径分布百分数为48.86%,载药量为48.19%,包封率为37.46%,在pH1.2、6.8和7.6,3种缓冲液中的释放时间为6-8h。结论:本法所制微球工艺稳定,在体外具有缓释作用。 |
| 中文关键词:甲硝唑 羧甲基壳聚糖 微球 体外释放 |
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| Preparation technology and in-vitro release characteristics of metronidazole-loaded carboxymethyl chitosan sustained-release microspheres |
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| Abstract:Objective: To study the optimum technology for preparing metronidazole-loaded carboxymethyl chitosan（MZ-CMC） microspheres by emulsification and cross-linking process and to investigate the in-vitro release characteristics of MZ-CMC microspheres.Methods:An orthogonal test,based on 4 factors including CMC concentration,MZ/CMC（W/W）,glutaradehyde/CMC（W/W） and agitation speed,was employed to determine the optimum preparetion technology of microspheres.The in vitro release behavior was recorded and evaluated.Results:For this 4 factors,the degree of influence on the quality of microspheres were gradually lower in the sequence of "agitation speed","MZ/CMC（W/W）","glutaradehyde/CMC（W/W）",and "CMC concentration".Prepared with optimized method in this test,the proportion of microspheres with diameter from 50-200 μm was 48.86%.The drug content was 48.19%,and the enveloping rate was 37.46%.The in virto release time was from 6-8 h in 3 types of buffer solution of pH1.2,6.8 and 7.6.Conclusion:The preparing technology for MZ-CMC microspheres used in this test is dependable,and the in vitro release of MZ from the microspheres is sustained. |
| keywords:metronidazole carboxymethyl chitosan microsphere in vitro release |
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