| 3种5-HT3受体拮抗剂预防肝癌患者介入治疗后恶心呕吐的疗效比较 |
| 投稿时间：2007-04-16 修订日期：2006-10-30 点此下载全文 |
| 引用本文：刘秋如,马爱英,沈杰.3种5-HT3受体拮抗剂预防肝癌患者介入治疗后恶心呕吐的疗效比较[J].药学实践杂志,2008,(1):43~45 |
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| 中文摘要:目的:探讨昂丹司琼、格拉司琼、托烷司琼对预防肝癌患者介入治疗后引起的恶心、呕吐的疗效。方法:将120例行介入治疗的患者(为原发性肝癌),随机分为4组,每组30例。A组(对照组),甲氧氯普胺40mg;B组,昂丹司琼8mg;C组,格拉司琼3mg;D组,托烷司琼5mg。在介入治疗术中未灌注化疗药物前,通过导管向动脉内注射止吐药物。观察并记录4组患者术后的恶心、呕吐等不良反应,采用补救药物的病例数,恶心的严重程度,病人对止吐药物的满意度。结果:B、C、D组恶心、呕吐的发生率小于A组(P<0.05),再次接受止吐药物的病人的百分率小于A组,D组的止吐疗效明显高于另外3组,比较有显著性差异(P<0.05);其不良反应发生次数也明显少于另外3组。结论:3种5-HT3受体拮抗剂对介入化疗栓塞术患者是有效的止吐药物,在肝癌介入治疗时,托烷司琼防止呕吐是一个更好的选择。 |
| 中文关键词:昂丹司琼 格拉司琼 托烷司琼 肝肿瘤 介入治疗 呕吐 预防 |
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| Effects of ondansetron,granisetron,and tropisetron on vomiting caused by transcatheter arterial chemoembolization (TACE) |
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| Abstract:Objective:To compare the prophylactic efficacy of ondansetron,granisetron,and tropisetron on vomiting caused by TACE. Methods: 120 patients(with primary hepatocellular carcinoma) were randomly divided into four groups to receive ondanstron,granisetron,tropisetron via liver artery injection (n=30) and combined with metoclopramide as controls (n=30).The antiemetic efficacies were compared among the four groups for 5 consecutive days after TACE. Results:The effective rate of tropisetron group was significantly higher than that of the control group (P<0.05).Conclusion:Tropisetron is an effective antiemetic drug in controlling vomiting caused by TACE and should be advocated in clinical practice. |
| keywords:ondansetron granisetron tropisetron liver neoplasms transarterial chemoembolization(TACE) vomit prevent |
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