| 7-氮杂吲哚-3-羧酸的合成工艺改进 |
| 投稿时间：2007-03-21 点此下载全文 |
| 引用本文：蒋骏航,吕加国,周有骏.7-氮杂吲哚-3-羧酸的合成工艺改进[J].药学实践杂志,2007,(5):312~314,345 |
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| 中文摘要:目的:改进7-氮杂吲哚-3-羧酸的合成工艺。方法:以丁二腈为起始原料,用四氢呋喃、乙酸乙酯、石油醚等代替了原工艺中的异丙醚,正庚烷,氯苯等,并对处理工艺进行了优化。结果:优化后的制备工艺成本低,毒性小,后处理方便,提高了产率。结论:新工艺总产率达到43.4%,更适合工业生产。 |
| 中文关键词:7-氮杂吲哚-3-羧酸 合成 工艺改进 |
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| Improvement of the synthetic process of 7-azaindol-3-carboxylic acid |
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| Abstract:Objective: To improve the synthetic process of 7-azaindol-3-carboxylic acid.Methods: The succinonitrile was taken as the original raw material.The isopropyl ether,n-heptane,and chlorobenzene, which were used in original technics,were subsituted by ethyl acetate,petroleun ether,and xylene respectively.The disposition technics was optimized.Results: The technics was successfully improved due to its low cost,small toxicity,convenient disposition and high yield.Conclusions: The higher overall yields was 43.4%.This improved method is more suitable for industrial production for its low cost. |
| keywords:7-Azaindol-3-carboxylic acid synthesis technical improvement |
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