| HPLC法测定盐酸托哌酮片含量 |
| 投稿时间：2007-03-22 点此下载全文 |
| 引用本文：叶夏.HPLC法测定盐酸托哌酮片含量[J].药学实践杂志,2007,(4):232~234 |
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| 中文摘要:目的:建立用HPLC法测定盐酸托哌酮片含量的方法。方法:采用Phenomenex Luna C18柱（250 mm×4.6 mm,5μm）,以乙腈-0.1 mol/L乙酸钠溶液（25:75）（用冰醋酸调节pH值至3.5）为流动相,流速为1.2 mL/min,检测波长261 nm。结果:盐酸托哌酮在20.2～202.0μg/mL浓度范围内与峰面积线性关系良好（r =0.999 99）,平均回收率99.9%,RSD=0.6%。结论:本法操作简便,快速准确,专属性强,结果重现性好,可作为盐酸托哌酮片质量控制方法。 |
| 中文关键词:高压液相色谱法 盐酸托哌酮片 含量测定 |
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| Determination of tolperisone hydrochloride tablets by HPLC |
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| Abstract:Objective:To establishe a HPLC method for determination of tolperisone hydrochloride tablets.Methods:A Phenome- nex Luna C~(18) column(250 mm×4.6 mm,5μm)was used,the mobile phases was consisted of acetonitrile-0.1 mol/L sodium acetate (25:75)(adjust pH to 3.5 with acetic acid glacial),the flow rate was 1.2mL/min,the detector wavelength was at 261 nm。Results: The linear range was 20.2～202.0μg,/mL(r=0.99999),the mean average recovery was 99.9% and RSD was 0.6%。Conclusion: The method is simple,rapid and accurate.It can be used to quality control the tolperisone hydrochloride tablets. |
| keywords:HPLC tolperisone hydrochloride tablet determination of content |
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