| 以玻璃酸钠为媒介对氯霉素在滴眼液中释放的影响 |
| 投稿时间：2006-04-14 点此下载全文 |
| 引用本文：李琦,王凤山,凌沛学,张天民.以玻璃酸钠为媒介对氯霉素在滴眼液中释放的影响[J].药学实践杂志,2007,(2):100~101 |
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| 中文摘要:目的:研究以玻璃酸钠为媒介对氯霉素在滴眼液中释放的影响因素。方法:配制各影响因素不同的氯霉素溶液,采用改良的Franz扩散池,测定药物的渗透速率。结果:增加溶液的黏度能减慢氯霉素的释放速率,其释放速率随着玻璃酸钠浓度的增加而降低,随着氯霉素浓度的增加而提高。结论:氯霉素在滴眼液中的释放速率与溶液的黏度和药物浓度有关,但通过增加溶液黏度使药物达到缓释的方法是有限度的。 |
| 中文关键词:玻璃酸钠 氯霉素 药物释放 |
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| Influence of sodium hyaluronate as vehicle on chloramphenicol release in eye drops |
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| Abstract:Objective:To study the influence factores of chloramphenicol release with sodium hyaluronate as vehicle in eye drops. Methods:The penetration rates of chloramphenicol were determined with modified Franz diffusion cell in solutions with different influ-ence factores.Results:The increase of solution viscosity could decrease the release rate of chloramphenicol.The release rates of chlor-amphenicol decreased with the concentrations of sodium hyaluronate increased and increased with the concentrations of chloramphenicol increased.Conclusion:The release rate of chloramphenicol in eye drops is concerned with viscosity of solution and drug concentration, but there is a limite to the drug sustained release by increasing viscosity of solution. |
| keywords:solution hyaluronate chloramphenicol drug release |
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