| 特非那定片溶出度检查和含量测定流动相的改进 |
| 投稿时间：2006-01-16 点此下载全文 |
| 引用本文：吴海雯.特非那定片溶出度检查和含量测定流动相的改进[J].药学实践杂志,2007,(2):98~99 |
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| 中文摘要:目的:对特非那定片标准中溶出度检查与含量测定的流动相进行选择,统一为一个流动相。方法:采用高效液相色谱法。结果:流动相Ⅲ为乙腈-磷酸盐缓冲液(50:50),其出峰时间最短,峰形良好且专属灵敏。结论:建议将两个检测项目中的流动相统一为流动相Ⅲ。 |
| 中文关键词:特非那定片 高效液相色谱法 溶出度 含量测定 |
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| Improvement on mobile phase of dissolution and determination of terfenadine tablets |
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| Abstract:Objective:To find a ideal and unified mobile phase both of dissolution test and content determination of terfenadine tablets.Methods:HPLC was used.Results:The mobile phaseⅢ[a mobile phase composed of acetonitrile-phosphate buffer(50:50)] was applied,t_R is shorter,the peak shape is better and the methods are specific and sensitive.Conclusion:The mobile phaseⅢis recommended as a ideal and unified mobile phase of dissolution and determination for terfenadine tablets. |
| keywords:terfenadine tablets HPLC method dissolution determination of content |
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