| 灯盏细辛和灯盏花素对戊巴比妥钠致小鼠催眠的影响 |
| 投稿时间：2006-12-25 点此下载全文 |
| 引用本文：林焕冰,钟文,李铁军,芮耀诚,徐江平,张卫东.灯盏细辛和灯盏花素对戊巴比妥钠致小鼠催眠的影响[J].药学实践杂志,2007,(2):85~87 |
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| 中文摘要:目的:观察灯盏细辛和灯盏花素对戊巴比妥钠催眠小鼠的影响。方法:将小鼠随机分为灯盏细辛组、灯盏花素组、纳洛酮组及生理盐水组,观察对阈上剂量和催眠剂量的戊巴比妥钠致小鼠睡眠的影响,并考察了对小鼠自发活动和对小鼠的平衡功能影响。结果:灯盏细辛组、灯盏花素组及纳洛酮组与生理盐水组比较,能显著延长阈上剂量戊巴比妥钠致小鼠入睡时间,缩短睡眠持续时间(P＜0．05);缩短催眠剂量戊巴比妥钠所致小鼠翻正反射消失的持续时间(P＜0．05);对小鼠自发活动和小鼠平衡功能无明显影响。结论:灯盏细辛和灯盏花素对戊巴比妥钠催眠小鼠有催醒作用。 |
| 中文关键词:灯盏细辛 灯盏花素 戊巴比妥钠 催眠作用 |
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| Influence of Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobarbital sodium in mice |
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| Abstract:Objective:To survey the influence of the Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobar-bital sodium in mice.Methods:ICR mice were randomly divided into 4 equal groups(Dengzhanxixin injection group,breviscapine group,naloxone hydrochloride group and sodium chloride group),effects of drug on mice hypnosis induced by pentoharbital sodium in suprathreshold dose or hypnotic dose was observed.Effects of drugs on mice spontaneous movement and equilibrium function was also observed.Results:Comparing with the group of sodium chloride,the group of Dengzhanxixin injection,breviscapine and naloxone hydrochloride significantly prolonged the time of falling asleep,shorted the duration of hypnosis induced by pentobarbital sodium in su-prathreshold dose in mice respectively(P＜0.05),shorted vanishing period of righting reflex in the mice induced by pentobarbital sodi-um in hypnotic dose(P＜0.05 ).Conclusion:Dengzhanxixin injection and breviscapine had arousal effects on pentobarbital sodium treated mice. |
| keywords:Dengzhanxixin injection breviscapine pentobarbital sodium hypnotic effect |
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