| 正交设计法优化硝酸益康唑的合成工艺 |
| 投稿时间：2006-08-30 点此下载全文 |
| 引用本文：邵律成,陈红,王小燕,何邦平,吕加国,盛春泉.正交设计法优化硝酸益康唑的合成工艺[J].药学实践杂志,2007,(2):102~103 |
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| 中文摘要:目的:优化抗真菌药物硝酸益康唑的合成工艺。方法:采用正交设计法,重点考察反应温度、催化剂、反应时间及溶剂四个因素对收率的影响。结果:溶剂对反应收率的影响最为显著,其次是反应时间和催化剂。结论:新工艺原料价廉易得,反应条件温和,后处理简便,收率高。 |
| 中文关键词:正交设计 益康唑 合成 |
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| Optimization of the synthesis of econazole nitrate by orthogonal experimental design |
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| Abstract:Objective:To optimize the synthesis of econazole nitrate,a useful antifungal agent.Methods:Orthogonal experimen-tal design is used and the influence of temperature,catalyst,reaction time and solvent on the yield is investigated.Results:Solvent is more important than reaction time and catalyst.Conclusion:The new method has several advantages such as cheap reactants,facile reaction condition,convenient operation and high yield. |
| keywords:orthogonal experimental design econazole nitrate synthesis |
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