利巴韦林和氟罗沙星葡萄糖注射液的配伍稳定性考察
投稿时间:2006-07-10    点此下载全文
引用本文:吴雪,张应辉,陈佳,莫小俊.利巴韦林和氟罗沙星葡萄糖注射液的配伍稳定性考察[J].药学实践杂志,2007,(1):26~30
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作者单位
吴雪 中国人民解放军第181医院药剂科,广西 桂林 541002 
张应辉 中国人民解放军第181医院药剂科,广西 桂林 541002 
陈佳 桂林医学院,06届毕业生广西桂林 541002 
莫小俊 桂林医学院,06届毕业生广西桂林 541002 
中文摘要:目的:考察氟罗沙星葡萄糖注射液和利巴韦林的配伍稳定性。方法:在25℃的避光和室内自然光条件下,用紫外分光光度法分别测定24 h内利巴韦林和氟罗沙星葡萄糖注射液配伍前后的含量变化情况,同时记录其外观及pH值变化。结果:利巴韦林和氟罗沙星平均回收率分别为99.52%,99.31%;RSD分别为0.450%,0.364%。常温放置6 h内配伍液外观、pH值、含量均无明显变化。结论:6 h内利巴韦林与氟罗沙星葡萄糖注射液配伍基本稳定。
中文关键词:氟罗沙星  利巴韦林  配伍稳定性
 
Study on stability of compatibility of fleroxacin and glucose injection with ribavirin injection
Abstract:Objective:To study the compatible stability of fleroxacin and glucose injection with ribavirin Injection.Methods:In the case of ambient temeratur(25℃),the changes in appearance and pH were observed,the content was determined by UV.Results:The average recoveries were 99.52% and 99.31%;RSD were 0.450% and 0.364%.The compatibility of fleroxaein and glucose injection with ribavirin injection had no significant changes in the aspect,pH,and content.Conclusin:The fleroxaein and glucose injection can be compatible with ribavirin injection,and be used within 6 h.
keywords:fleroxacin  ribavirin  compatibility  stability
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