| 注射用复方氨苄西林钠药代动力学研究 |
| 投稿时间：2005-01-11 点此下载全文 |
| 引用本文：王佩贤,曹永孝,杨孝江,姚鸿萍,王秀芹.注射用复方氨苄西林钠药代动力学研究[J].药学实践杂志,2007,(1):18~20,30 |
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| 中文摘要:目的:考察注射用复方氨苄西林钠的药代动力学特征。方法:HPLC法检测注射家兔后不同时间血浆的氨苄西林与丙磺舒药代动力学参数。结果:以氨苄西林钠计,注射用复方氨苄西林钠300 mg/kg组能够显著的增加氨苄西林半衰期,由(23±10)min增至(31±15) min,AUC由(8．5±0．9)mg/(h·mL)增至(6．2±0．8) mg/(h·mL),注射用复方氨苄西林钠120 mg/kg组氨苄西林AUC由(2．8±0．9)mg/(h·mL)增至(5．7±1．0)mg/(h·mL),注射用复方氨苄西林钠50 mg/kg组氨苄西林AUC由(0．7±0．2)mg/(h·mL)增至(1．5±0．3)mg/(h·mL)(P＜0．05或P＜0．01)。结论:注射用复方氨苄西林钠具有增强注射用氨苄西林钠活性的作用。 |
| 中文关键词:复方氨苄西林钠 氨苄西林钠 丙磺舒 药代动力学 |
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| Studies of the pharmacokinetics of compound ampicillin sodium for injection |
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| Abstract:Objective:To observe the characteristics of the pharmacokinetics of compound ampicillin sodium for injection.Meth- otis:The pharmacokinetics of ampieillin and probenecid in six rabbits after injection were measured by HPLC.Results:On calculation of quantity of ampieillin sodium,300 mg/kg compound ampicillin sodium increased the half life of ampicillin from(23±10)to(31±15)min and the value of A UC from(8.5±0.9 )to(6.2±0.8)mg/(h·mL),120 mg/kg compound ampicillin sodium increased the value of AUC from(2.8±0.9)to(5.7±1.0)mg/(h·mL),50 mg/kg compound ampicillin sodium increased the value of AUC from(0.7±0.2)to(1.5±0.3)mg/(h·mL).Conclusion:Compound ampicillin sodium for injection can increase the activity of ampicillin sodium. |
| keywords:compound ampicillin sodium ampicillin sodium probenecid pharmacokinetics |
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