| 西替伪麻缓释片中盐酸伪麻黄碱的动物药代动力学研究 |
| 投稿时间：2005-12-27 点此下载全文 |
| 引用本文：吕竹芬,谢清春,陈燕忠,申楼,周松.西替伪麻缓释片中盐酸伪麻黄碱的动物药代动力学研究[J].药学实践杂志,2006,(6):342~345 |
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| 基金项目:广东省科技攻关项目(编号2005B30101002) |
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| 中文摘要:目的：采用高效液相色谱法测定Beagle犬体内盐酸伪麻黄碱血药浓度,并对其药动学参数、相对生物利用度及体内外的相关性作初步研究。方法：Beagle犬6只,单次口服西替伪麻缓释片2片．用HPLC法,采用DiamonsilTMC18色谱柱（5μm,250×4．6mm）,0．05mol/L的磷酸二氢钠溶液-甲醇（75：25）,以磷酸调节pH3．0为流动相,盐酸苯丙醇胺为内标,检测波长213nm,测定血浆中的药物浓度。结果：盐酸伪麻黄碱的相对生物利用度为（95．9±2．3）%,单次口服西替伪麻缓释片药动学参数分别为MRT=8．21h,Tpeak=4h,Cmax=2008．7ng/mL。结论：经统计数据分析自制片与对照片药动学过程相似,生物利用度等效,并且自制片体内外累积释放有着良好的相关性。 |
| 中文关键词:缓释片 西替伪麻 药代动力学 |
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| Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs |
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| Abstract:Objective:To study the pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs. Methods:Pseudoephedrine concentrations in serum were assayed by HPLC with DiamonsilTM C18（250×4.6 mm,5μm） column, 0.05mol/L sodium dihydrogen phosphate-mathanol（75:25）,pH adjusted to 3.0 with phosphoric acid as mobile phase,and detec- tion wavelength of 213nm.The pharmacokinetic parameters were researched after single admininstration of cetirizine/pseudoephedrine sustained release tablets in 6 Beagle dogs.Results:The pharmacokinetic parameters cetirizine/pseudoephedrine sustained release tablets were followed:MRT=8.21 h,Tpeak=4h,Cmax=200 8.7ng/mL.The relative hioavailabihy of cetirizine/pseudoephedrine sustained release tablets was（95.9±2.3）%.Conclusion:The pharmacokinetic profile of cetirizine/pseudoephedrine sustained release tablets was similar to the reference tablets.The self-made one was bioequivalent to Zycted-D 12h tablets,and its released profile in vivo/in vitro was correlation. |
| keywords:sustained release tablets cetirizine/pseudoephedrine pharmacokinetic |
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