| 电导法测定多硫酸肝素钠中硫酸基含量 |
| 投稿时间：2006-01-18 点此下载全文 |
| 引用本文：金艳,崔慧斐,凌沛学,张天民.电导法测定多硫酸肝素钠中硫酸基含量[J].药学实践杂志,2006,(4):205~206 |
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| 中文摘要:目的:建立一种测定多硫酸肝素钠中硫酸基含量的方法。方法:将多硫酸肝素钠通过H+型阳离子树脂,用氢氧化钠对其洗脱液进行滴定,通过电导率的变化确定滴定终点,并用氯代十六烷基吡啶对结果进行校正,测定其硫酸基含量。结果:硫酸基的平均加样回收率为100．18％,RSD为3．67％。结论:本法简便准确,重复性较好。 |
| 中文关键词:多硫酸肝素钠 硫酸基 氯代十六烷基吡啶 含量测定 |
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| Determination of sulfate groups in polysulfated heparin sodium with conductometry |
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| Abstract:Objective:To establish a method for the determination of the contents of sulfate groups in polysulfated heparin sodium. Methods:The contents of sulfate groups were determined by converting the Na+ of polysulfated heparin sodium into H+ with cation exchange resin and titrating with sodium hydroxide. The titration end-point was ascertained by variance of conductivity and the results were rectified by cetylpyridinium chloride. Results:The average recovery was 100. 18% ,RSD = 3. 67% . Conclusion:This mthod was simple,reproducible and accurate. |
| keywords:polysulfated heparin sodium sulfate group cetylpyridinium chloride assay |
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