| 注射用氨苄西林钠／氯唑西林钠与不同溶媒配伍稳定性的研究 |
| 投稿时间：2005-06-10 点此下载全文 |
| 引用本文：张利斌,张晓庆,刘明忠.注射用氨苄西林钠／氯唑西林钠与不同溶媒配伍稳定性的研究[J].药学实践杂志,2006,(2):86~89 |
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| 中文摘要:目的:研究注射用氨苄西林钠／氯唑西林钠(氨氯青霉素钠)与5种常用输液在不同放置时间、不同温度下的配伍稳定性。方法:将注射用氨苄西林钠／氯唑西林钠用5种常用输液分别配成溶液,用高效液相色谱法测定各配伍液中氨苄西林钠、氯唑西林钠的含量。结果:样品与5％葡萄糖注射液和葡萄糖氯化钠注射液配伍时,随着放置时间和温度的升高,各组溶液中氨苄西林钠和氯唑西林钠的含量下降,其中以葡萄糖注射液中者最为显著。结论:氨氯青霉素钠在5％葡萄糖和葡萄糖氯化钠注射液中不稳定。 |
| 中文关键词:氨苄西林钠 氯唑西林钠 配伍性 稳定性 |
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| Study on compatible stability of ampicloxacillin sodium for injection in five infusions |
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| Abstract:Objective: To investigate the compatible stability of ampicoxacillin sodium for injection in five infusions in different time and different temperature conditions.Methods: Ampicloxacillin sodium was dissolved in five infusions.Ampicillin and cloxacillin in ampicloxacillin sodium for injection were determined by HPLC,and the color changes of all infusions were observed.Results: The ampicillin and eloxacillin contents in ampicloxacillin sodium for injection declined with time and temperature increased.The most distinct were 5% glucose injection.Concision: Ampicloxacillin sodium for injection wasn't stable in 5% glucose, gluscose and sodium chloride injection. |
| keywords:ampicloxacillin ampicillin cloxacillin compatibility stability. |
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