| 6种黄酮化合物对大鼠肝星状细胞胶原合成的抑制作用 |
| 投稿时间：2005-09-14 点此下载全文 |
| 引用本文：刘晔,齐荔红,章越凡,肖振宇,张珉,张俊平.6种黄酮化合物对大鼠肝星状细胞胶原合成的抑制作用[J].药学实践杂志,2006,(2):83~86 |
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| 基金项目:国家自然科学基金资助项目(No.30171087) |
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| 中文摘要:目的:研究黄颜木素、槲皮素、芹菜素、根皮素、橙皮素和查尔酮对血清、巨噬细胞培养上清液和转化生长因子β1刺激的大鼠肝星状细胞HSC-T6胶原合成的影响。方法:3H-脯氨酸掺入法测定细胞胶原合成。结果:黄颜木素、槲皮素、芹菜素、根皮素、橙皮素和查尔酮(12.5～50μmol／L)以浓度依赖方式抑制血清、巨噬细胞上清和转化生长因子β1诱导的胶原合成。结论:黄颜木素、槲皮素、芹菜素、根皮素、橙皮素和查尔酮具有抑制肝星状细胞胶原合成的作用,可能具有潜在的肝纤维化治疗作用。 |
| 中文关键词:黄酮 星状细胞 胶原 巨噬细胞 转化生长因子 |
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| Inhibitory effects of six flavonoids on collagen synthesis of rat hepatic stellate cells |
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| Abstract:Objective: To study the effects of six flavonoids (fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone)on collagen synthesis of immortallized rat hepatic stellate cell line HSC-T6 cells.Methods: Collagen synthesis was determined by 3H-proline incorporation.Results:Fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone (12.5-50μmol/L)concentration-dependently diminished collagen synthesis stimulated by serum, macrophage conditioned medium (MCM)and transforming growth factorβ1(TGFβ1).Conclusion:The six flavonoids inhibited the collagen synthesis of hepatic stellate cells, which may have potential therapeutic effects against liver fibrosis. |
| keywords:flavonoid hepatic stellate cells collagen macrophages transforming growth factor |
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