| 清知源软胶囊对高脂血症大鼠血脂及抗氧化活性的影响 |
| 投稿时间：2005-10-27 点此下载全文 |
| 引用本文：姜涛,秦路平,郑汉臣,韩婷.清知源软胶囊对高脂血症大鼠血脂及抗氧化活性的影响[J].药学实践杂志,2006,(2):81~83 |
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| 基金项目:上海市科委基金资助项目(No.034958037);上海市浦东新区科技创业人才资金资助项目(No.2002-28). |
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| 中文摘要:目的:研究清知源软胶囊对大鼠血脂的调节作用以及抗氧化活性的影响。方法:采用50只健康 Wistar大鼠按照体重和血脂水平随机分成5组,分别接受正常饲料、高脂模型对照、高脂饲料加入清知源软胶囊(高、低剂量分别为20、5mg／kg)、阳性药对照灌胃处理。3周后取血测定血脂和抗氧化酶的含量。结果:与高脂模型组大鼠相比,清知源软胶囊组可以显著降低大鼠血清TC、TG、LDL-C、MDA含量,升高血清 HDL-C含量,使血清和肝组织超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性上升,丙二醛 (MDA)含量降低(P<0.05)。结论:清知源软胶囊可以明显地调节血脂,提高抗氧化能力,抑制脂质过氧化。 |
| 中文关键词:清知源软胶囊 抗氧化 高脂血症 |
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| Effects of Qingzhiyuan soft capsule on blood lipid and antioxidantion in hyperlip-idemia rats |
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| Abstract:Objective: To study the effects of Qingzhiyuan soft capsule(QZY)on blood lipid and antioxidant activity in hyperlipi-demia rats.Methods: Fifty Wister rats were randomly divided into five groups according to body weight and serum cholesterol levels.They were fed one of five diets, a reference diet, a high fat supplemented diet and a high fat supplemented with 20mg/kg, 5mg/kg QZY, a positive diets.After three weeks, blood lipid and antioxidant activity were determined respectively.Results: Compared with model, QZY could reduced the serum TC, TG, LDL-C concentration, increased SOD and GSH-Px activities, decreased MDA level significantly(P<0.05).Conclusion: QZY might play an important role in preventing hyperlipidemia through its antioxidative effect. |
| keywords:Qingzhiyuan soft capsule antioxidation hyperlipidemia |
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