| 高效液相色谱-蒸发光散射法测定白消安片的含量 |
| 投稿时间：2005-07-08 点此下载全文 |
| 引用本文：岳昌林,郭忠.高效液相色谱-蒸发光散射法测定白消安片的含量[J].药学实践杂志,2006,(1):25~27 |
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| 中文摘要:目的:建立HPLC-ELSD法考察并测定白消安片中白消安的含量。方法:SHIMADZU C8柱(250mm×4.6min,5μm),流动相:水:乙腈(75:25),流速:1.0mL／min,载气:氮气,载气流速:2.0bar。结果:白消安在浓度0.25-0.75mg／mL范围内与峰面积的对数呈良好的线性关系,r为0.9999。平均回收率为99.7％。结论:本方法专属性好,准确,可用于该制剂中白消安含量的测定。 |
| 中文关键词:白消安 HPLC-ELSD 含量测定 |
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| Quantitative determination of content in Busulfan's tablets by HPLC-ELSD |
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| Abstract:Objective:To establish a HPLC-ELSD method for determining the content of busulfan in busulfan tablets.Methods: The chromatographic conditions were as follows:SHIMADZU C8 column(250mm×4.6mm,5μm),the mobile phase:water-acetonitrile (75-25),the flow rate:1.0mL/min,and the detector:ELSD,the carrier gas:nitrogen,the flow rate:2.0 bar.Results:The standard curve of busulfan was linear over the rage of 0. 25-0.75mg/mL(r=0.9999).The average recovery was 99.7%.Conclusion:This method is accurate and specificity,and it can be used on the quality control of busulfan tablets. |
| keywords:HPLC-ELSD busulfan determination of content |
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