| 大鼠胃粘膜癌前病变实验动物模型的建立 |
| 投稿时间：2005-02-01 点此下载全文 |
| 引用本文：王少明,林才经,杨春波,施作霖,庄捷,阮君山.大鼠胃粘膜癌前病变实验动物模型的建立[J].药学实践杂志,2005,(5):271~272,281 |
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| 作者 | 单位 | | 王少明 | 福建省立医院, 福建, 福州, 350001 | | 林才经 | 福建省立医院, 福建, 福州, 350001 | | 杨春波 | 福建省第二人民医院, 福建, 福州, 350001 | | 施作霖 | 福建省立医院, 福建, 福州, 350001 | | 庄捷 | 福建省立医院, 福建, 福州, 350001 | | 阮君山 | 福建省立医院, 福建, 福州, 350001 |
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| 基金项目:福建省中医药重点项目资助 |
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| 中文摘要:目的 建立大鼠胃粘膜癌前病变实验动物模型.方法 将大鼠随机分成单纯应用小剂量甲基硝基亚硝基胍(MNNG)溶液自由饮用的模型1组和综合应用MNNG和雷尼替丁并辅以乙醇灌胃及饥饱失常的多因素造模方法的模型2组,及空白对照组.并比较两模型组的差异.结果 病理观察显示模型制造成功.结论 本研究所用的造模方法的胃粘膜萎缩的发生率较单纯应用致癌剂MNNG明显增高,同时时间由文献报道的35周缩短为20周,是一个较为理想的胃癌前病变的模型,可用于胃癌前病变的发生机理及药物对其防治疗效作用等的研究. |
| 中文关键词:胃粘膜 癌前病变 实验研究 动物模型 |
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| Study on the model of gastric mucosal precancerous lesion in rat |
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| Abstract:Objective To establish a practical and effective animal model in order to study gastric mucosal precancerous lesion (GPL) in rat. Methods Three group were classified in the experimental. Normal group:not to establish the model; Model group Ⅰ established the model only use N-methyl-N'-nitro-N'-nitrosoguanididne (MNNG). Model group Ⅱ:established the model by com-plexed method such as the diet, N-methyl-N'-nirtro-N-nitrosoguanidine(MNNG), alcohol, ranitidine and so on. The change of GPL in pathohistologic were observed. Results Experimental GPL of rats were induced successfully. Conclusion It was found that the rate of GPL in model group Ⅱ is higher than that in model group Ⅰ. And the established time was only 20 weeks which was less than 35 weeks that have ever reproted. The model is a practical and effective animal model in studying on GPL in rat. |
| keywords:gastric mucosal precancerous lesion experimental study animal model |
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