| KNT009安全性药理学研究 |
| 投稿时间：2005-06-16 点此下载全文 |
| 引用本文：姜华,陆国才,袁伯俊,栗志远,佘佳红.KNT009安全性药理学研究[J].药学实践杂志,2005,(5):266~269 |
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| 作者 | 单位 | | 姜华 | 第二军医大学基础部新药评价中心, 上海, 200433 | | 陆国才 | 第二军医大学基础部新药评价中心, 上海, 200433 | | 袁伯俊 | 第二军医大学基础部新药评价中心, 上海, 200433 | | 栗志远 | 第二军医大学基础部新药评价中心, 上海, 200433 | | 佘佳红 | 第二军医大学基础部新药评价中心, 上海, 200433 |
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| 中文摘要:目的 观察KNT009对小鼠神经系统、犬心血管系统及呼吸系统的影响.方法 实验均分高、中、低剂量组及空白对照和阳性对照共5个组,小鼠实验给药组分别单次慢速静脉注射(iv)KNT009 160、80和40 mg/kg,加替沙星80 mg/kg,观察动物的自发活动和爬杆能力;犬实验给药组分别单次慢速iv KNT009 40、20 和10 mg/kg,加替沙星20 mg/kg,观察药物对犬血压、ECG、呼吸频率及节律的影响.结果 单次慢速iv KNT009对小鼠自发活动和爬杆能力无明显影响.单次慢速iv KNT009可降低犬收缩压、舒张压、平均动脉压,减慢心率,延长QT间期,使犬呼吸频率减慢,呼吸幅度加大,且均存在量效关系,3 h后上述指标基本恢复正常,加替沙星也有类似变化.结论 KNT009对心血管和呼吸系统有一定的影响,可使血压下降,心率减慢,QT间期延长,呼吸频率减慢,呼吸幅度加大. |
| 中文关键词:KNT009 安全性药理 心血管系统 呼吸系统 神经系统 |
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| Safety pharmacology study of KNT009 |
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| Abstract:Objective To study the effects of KNT009 on nervous, cardiovascular and respiratory system in animals. Methods Mice were randomly divided to receive single 160, 80, 40, and 0 mg/kg dose of KNT009 and 80 mg/kg dose of gatigloxacin respectively and the spontaneous activities and pull-down ability of animals were observed. Dogs were randomly divided to receive single 40, 20, 10 and 0 mg/kg dose of KNT009 and 20 mg/kg dose of gatigloxacin respectively and the blood pressure, ECG, respiratory rate and width of dogs were measured. Results No effects on spontaneous activities and pull-down ability in mice were observed. The systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate and respiratory rate of dogs were decreased, the QT interval was prolonged and the respiratory width was increased in dogs, and there were dose effective relationship, however, these parameters return to normal within 3h. Conclusion KNT009 has some effects on cardiovascular system in dogs such as the blood pressure and heart rate may be decreased and the QT interval may be prolonged, KNT009 also has some effects on respiratory system in dogs such as the respiratory rate may be decreased and the respiratory width may be increased. |
| keywords:KNT009 safety pharmacology cardiovascular system respiratory system nervous system |
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