| 双波长倍率系数法和一阶导数光谱法测定复方苯甲酸酊的含量 |
| 投稿时间：2003-12-16 点此下载全文 |
| 引用本文：顾伟鹰,张和平,黄伟芬.双波长倍率系数法和一阶导数光谱法测定复方苯甲酸酊的含量[J].药学实践杂志,2004,(5):276~277 |
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| 中文摘要:目的 建立复方苯甲酸酊中苯甲酸和水杨酸的含量测定方法。方法 采用倍率系数法于(272±1)nm和(301±1)nm波长处直接测定苯甲酸含量;采用一阶导数光谱法于(318±1)nm波长处直接测定水杨酸的含量。结果 苯甲酸:在19.34～27.08μg/mL浓度范围内,线性关系良好,相关系数r=0.999 9,平均回收率99.4%,RSD为0.80%。水杨酸:在24.48～34.27μg/mL浓度范围内,线性关系良好,相关系数r=0.999 9,平均回收率99.6%,RSD为0.490A。结论 本方法简便、快速、准确。 |
| 中文关键词:双波长倍率系数法 一阶导数光谱法 复方苯甲酸酊 苯甲酸 水杨酸 含量测定 |
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| Determination of compound benzoic acid tincture by dual-wavelength ratio coef-ficient spectrometry and first derivative spectrometry |
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| Abstract:Objective To establish a quantitative analysis method for benzoic acid and salicylic acid in compound benzoic acid tincture. Methods The benzoic acid was determined directly at 272 and 301 nm by dual-wavelength ratio coefficient spectrometry. The salicylic acid was determined directly at 318nm by first derivative spectrometry. Results The calibration curve of benzoic acid was linear in the range from 19.34 to 27.08μg/mL with r =0.9999,the average recovery and relative standard deviation were 99.4% and 0.80% respectively. The calibration curve of salicylic acid was linear in the range from 24.48 to 34.27μg/mL with r =0.9999, the average recovery and RSD were 99.6% and 0.49% respectively. Conclusion The method is simple,rapid and accurate. |
| keywords:dual-wavelength ratio coefficient spectrometry first derivative spectrometry compound benzoic acid tincture benzoicacid salicylic acid determination of content |
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