| 离子对反相高效液相色谱法测定氢溴酸东莨菪碱注射液的含量 |
| 投稿时间：2004-01-10 点此下载全文 |
| 引用本文：赵平鸽.离子对反相高效液相色谱法测定氢溴酸东莨菪碱注射液的含量[J].药学实践杂志,2004,(3):165~166 |
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| 中文摘要:目的 建立离子对反相高效液相色谱法测定氢溴酸东莨菪碱注射液的含量。方法 流动相为甲醇20mmol/L庚烷磺酸钠溶液-冰醋酸 (50:50:2),流速0.9mL/min,ZORBAX SB-C18色谱柱 (4.6×250mm,5μm),检测波长225nm。 结果 线性范围为0.1～0.5mg/mL(r =0.9998),平均回收率为101.15%,RSD为1.58%。结论 本法简便、快速,结果准确,适用于氢溴酸东莨菪碱注射液的质量控制。 |
| 中文关键词:氢溴酸东莨菪碱注射液 离子对反相高效液相色谱法 |
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| Determination of scopolamine hydrobromide injection by ion-pair RP-HPLC |
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| Abstract:Objective To establish a method to determinate scopolamine hydrobromide injection by ion pair RP-HPLC.Methods The mobile phase of methanol-20mmol/L sodium heptanesulfonate solution acetic acid (50:50:2) and ZORBAX SB-C18 column (4.6×250mm,5μm)was used,the flow rate was 0.9mL/min and the detect wavelength was 225nm.Results The linear range of scopolaminc hydrobromide was 0.1～0.5mg/mL(r=0.9999). The average recovery was 100.15%,RSD was 1.58%.Conclusion The method was simple,rapid and accurate. It can be used to control the quality of scopolamine hydrobromide injection. |
| keywords:scopolamine hydrobromide injection ion-pair RP-HPLC |
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