| 盐酸西布曲明片的溶出度测定 |
| 投稿时间：2003-10-28 点此下载全文 |
| 引用本文：高素英,陈雪帆.盐酸西布曲明片的溶出度测定[J].药学实践杂志,2003,(6):371~373 |
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| 中文摘要:目的 建立盐酸西布曲明片溶出的测定方法。方法 用HPLC法测定盐酸西布曲明片的溶出度。色谱柱为Shimadzu VP-ODS柱,流动相为甲醇-0.05mol/L KH2PO4(用磷酸调pH至3.0)(70:30),流速1.0mL/min,检测波长为223nm,线性范围为5.0-50.0μg/mL,平均回收率为100.6%,RSD为0.94%。结论 该方法线性关系良好、回收率高,可以用来控制盐酸西布曲明中的质量。 |
| 中文关键词:盐酸西布曲明 溶出度 |
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| Determination of dissolution of sibutramine hydrochloride tablets by HPLC |
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| Abstract:OBJECTIVE Dissolution of sibutramine hydrochloride tablet was determinated by HPLC. The chromatography conditions were as follows:Column, Shimadzu VP-ODS; mobile phase:methol -0.05mol/L KH2PO4(adjusted to pH 3.0 with H3P04)(70:30);velocity of flow:1mL/min;detection wavelength:223nm. The linear ranges were 5.0-50.0μg/mL. The average recoveries were 100.6%. |
| keywords:sibutramine hydrochloride dissolution HPLC |
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