盐酸罂粟碱氯化钠注射液细菌内毒素检测法实验研究
投稿时间:2003-10-28    点此下载全文
引用本文:金卫红,居红枫.盐酸罂粟碱氯化钠注射液细菌内毒素检测法实验研究[J].药学实践杂志,2003,(6):341~343
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作者单位
金卫红 江苏省药品检验所, 江苏 南京 210008 
居红枫 江苏省药品检验所, 江苏 南京 210008 
中文摘要:目的 建立盐酸罂粟碱氯化钠注射液的细菌内毒素检查方法。方法 用两个生产厂的鲎试剂对盐酸罂粟碱氯化钠注射液进行干扰试验研究。结果 盐酸罂粟碱氯化钠注射液对细菌内毒素检查无干扰作用。结论 可以用细菌内毒素检查法(凝胶法)代替家兔热原检查法控制其热原。
中文关键词:盐酸罂粟碱氯化钠注射液  细菌内毒素  凝胶法
 
Assay for bacteririal endotoxin in papaverine hydrochloride and sodium chloride injection
Abstract:OBJECTIVE To establish the method of assay for the bacterial endotoxin in papaverine hydrochlo-ride and sodium chloride injection. METHODS Inhibition and enhancement test was performed with limulus ameboeytc lysate manufactured by two different companies. RESULTS:The injection will not interfere to the bacterial endotoxins test. CONCLUSIONS The results suggest that bacterial endotoxins test(gel-clot method)can be used as an replaceable method for the rabbit pyrogen test for papaverine hydrochloride and sodium chloride injection.
keywords:papaverine hydrochloride and sodium chlorid injection  bacterial endotoxin  Gel-clot method
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