| 罗红霉素电子药膜含量测定方法的研究 |
| 投稿时间：2002-04-22 点此下载全文 |
| 引用本文：王晓波,王敬国,袭荣刚.罗红霉素电子药膜含量测定方法的研究[J].药学实践杂志,2002,(5):293~295 |
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| 中文摘要:目的 建立测定罗红霉素电子药膜中主药含量的方法。方法 采用高效液相色谱法,色谱柱为YWG C18柱,流动相为乙腈-甲醇-0.5%乙酸铵 (100:80:60),检测波长为 235nm.结果 精密度及稳定性均良好,在 0.3～1.7mg·ml-1范围内,峰面积与浓度 (mg·ml-1)呈良好的线性关系,r=0.9998,平均回收率为 99.23%,RSD为 0.84%.n=5.结论 本方法简便、专属、重现性好,可用于罗红霉素电子药膜剂的含量测定。 |
| 中文关键词:电子药膜 罗红霉素 HPLC 含量测定 |
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| Studies on assay of roxithromycin in electron medicinal membrane of roxithromycin |
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| Abstract:OBJECTIVE To develop a method for assay of roxithromycin in electron medicinal membrane of roxithromycin. METHODS To use a HPLC method by YWG C18 column. The mobile phase was a mixture of acetonitrile-methano-l0.5% ammonium acetate(100:80:60),with the detection wavelength at 235 nm.RESULTS Precision and stability were fine. The linear correlation was observed from the concentrations of 0.3 to 1.7mg·ml-1(r=0.9998).The average recovery was 99.23%.Resolution bettween roxithromycin and other peaks met the requirements.CONCLUSION The method is convenient, selective and reproducible. |
| keywords:electron medicinal membrane roxithromycin HPLC content determination |
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