| 紫外分光光度法测定盐酸丁卡因滴眼液的含量 |
| 投稿时间：2002-04-15 点此下载全文 |
| 引用本文：农格.紫外分光光度法测定盐酸丁卡因滴眼液的含量[J].药学实践杂志,2002,(5):285~286 |
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| 中文摘要:目的 建立紫外分光光度法测定盐酸丁卡因的含量。方法 pH7.4磷酸盐缓冲液为空白,在波长为312nm处测得盐酸丁卡因有最大吸收,处方中的氯化钠及羟苯乙酯在测定浓度下无干扰。结果 紫外分光光度法与非水溶液滴定法含量测定结果相比较,前者平均回收率为 100.09%,RSD%为 1.06%,n=3,后者平均回收率为 99.93%,RSD为 0.98%,n=3,t检验表明两者无显着性差异 (P >0.05).结论 该方法简便易行,精密度高,可作为该制剂的质量控制方法。 |
| 中文关键词:紫外分光光度法 盐酸丁卡因滴眼液 含量测定 |
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| Determination of content in tetracaine hydrochloride eye drops by UV-spectrophotometry |
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| Abstract:OBJECTIVE To establish UV method for the determination of content in tetracaine hydrochloride eye drops.METHODS UV spectrophotometry was used to determine the tetracaine hydrochloride eye drops.The sample was determined at 312nm. RESULTS The standanl curver was good linear within the range of 3.5-10.5μg·ml-1,(r=0.9999)。The average recovery was 100.09%,RSD was 1.06%(n=3).CONCLUSIGN The method is simple, reliable, accurate and can be used for the determination of the content of tetracaine hydrochloride eye drops. |
| keywords:UV-spectrophotometry tetracaine hydrochloride eye drops,quantitive determination |
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