青霉素Ⅴ钾分散片的研制

彭毓芳; 贺林; 张志荣; 吴苏澄; 蒋红艳

青霉素Ⅴ钾分散片的研制

投稿时间：2001-03-05 点此下载全文

引用本文：彭毓芳,贺林,张志荣,吴苏澄,蒋红艳.青霉素Ⅴ钾分散片的研制[J].药学实践杂志,2001,(5):275~276

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作者	单位
彭毓芳	成都市儿童医院, 成都 610017
贺林	成都市儿童医院, 成都 610017
张志荣	华西医科大学, 成都 610041
吴苏澄	成都军区总医院, 成都 610083
蒋红艳	华西医科大学, 成都 610041

中文摘要:目的筛选青霉素Ⅴ钾分散片的处方。建立青霉素Ⅴ钾分散片的含量测定方法。方法采用均匀设计法筛选处方;紫外分析法测定含量。结果青霉素 Ⅴ钾分散片崩解时限45～90s,T₅₀ 1.09min,T_d 2.07min;紫外测定回收率97.54%。结论按本文处方生产的青霉素Ⅴ钾分散片质量符合英国药典对分散片的要求;紫外方法快速、简便,准确度较高。

中文关键词:青霉素Ⅴ钾分散片均匀设计

Research of phenoxymethylpenicillin potassium dispersible tablets

Abstract:OBJECTIVE To optimize prescriptions of phenoxymethylpenicillin potassium (VK) dispersible tablets and establishe content measuring method. METHODS Uniform design method and UV method were used. RESULTS The results were as follows:breaking time 45～90s, T₅₀ 1.09min, T_d 2.07min, recovery ratio 97.54%. CONCLUSION The quality of phenoxymethylpeniniclillin potassium dispersible tablets is conform to Britain Pharmacopoeia and UV method is simple and rapid.

keywords:phenoxymethylpenicillin potassium dispersible tablets uniform design

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