| 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响 |
| 投稿时间：2001-04-24 点此下载全文 |
| 引用本文：李小宁,卫新国,尚云,卫洪昌,朱晓梅,孙平龙,严世芸.黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J].药学实践杂志,2001,(5):270~272 |
| 摘要点击次数: 1337 |
| 全文下载次数: 914 |
|
|
| 中文摘要:目的 探讨黄芪保心汤地实验性急性心肌缺血大鼠血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平的影响。方法 44只大白鼠随机分为4组:假手术组,模型对照组,黄芪保心汤组,复方丹参滴丸组。结扎左冠状动脉前降支造成急性心肌缺血模型,观察3h后,从腹主动脉取血检测血浆ET、CGRP水平。结果 黄芪保心汤组,能显着降低血浆ET含量(P<0.001),升高血浆GGRP水平(P<0.01)。结论 以益气活血祛痰化浊为主的黄芪保心汤有调节急性心肌缺血时血浆ET、CGRP水平失衡的作用,改善心肌缺血、缺氧状态,减少心肌缺血损伤,且作用优于复方丹参滴丸。 |
| 中文关键词:急性实验性心肌缺血 内皮素 降钙素基因相关肽 黄芪保心汤 |
| |
| Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction |
|
|
| Abstract:OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP. |
| keywords:astragalus heart-keeping decoction acute myocardial infarction experimental study ET CGFIP |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
