| 他莫昔酚对耐药细胞系K562/DOX多药耐药逆转作用的研究 |
| 投稿时间：2000-11-20 点此下载全文 |
| 引用本文：梁延春,王秀丽.他莫昔酚对耐药细胞系K562/DOX多药耐药逆转作用的研究[J].药学实践杂志,2001,(5):264~265 |
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| 中文摘要:目的 寻找有效的多药耐药逆转剂。方法 以他莫昔酚作为耐药逆转剂,用[溴化-3(4,5-二甲基-2-噻唑基)-2,5-二苯基四唑氮]MTT法体外药物敏感试验,观察他莫昔酚对多药耐药白血病细胞株K562/DOX的药物敏感性的影响。结果 他莫昔酚可增强阿霉素(DOX)对K562/DOX的细胞毒作用,对K562细胞无影响。结论 他莫昔酚是一种有效的多药耐药逆转剂。 |
| 中文关键词:他莫昔酚 药物耐受性 耐药逆转剂 |
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| Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX |
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| Abstract:OBJECTIVE To develop effect of tamoxifen on resistance modulators. METHODS The effects of tamoxifen on drug sensitivity in multidrug resistant human leukemic cell line K562/DOX were studied by MTT corlori- metric assay. RESULTS:Tamoxifen enhanced the cytotoxicity of doxorubicin (DOX) to K562/DOX and had no effect on efflux of DOX in K562 cells. CONCLUSION Tamoxifen is an effective reversal agent of multidrug resistance. |
| keywords:tamoxifen trug tolerance effective reversal agent |
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